During development of biological organisms, multiple complex structures are formed.In many instances, these structures need to exhibit a high degree of order to be functional, although many of their constituents are intrinsically stochastic.Hence, it has been suggested that biological robustness ultimately must rely on complex gene regulatory netwo
Deep Learning achieves state-of-the-art results in many domains, yet its black-box nature limits its application to real-world contexts.An intuitive way to improve the interpretability of Deep Learning models is by Vacuum Performance Kit explaining their decisions with similar cases.However, case-based explanations cannot be used in contexts where
Bob Z Wang, Elsie Chan, Rasik B Vajpayee The Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia; Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia Background: The purpose was to determine preoperative indications, intraoperative procedures, and outcomes of capsular tension ring (C
Public gene expression databases are a rapidly expanding resource of organism responses to diverse perturbations, presenting both an opportunity and a challenge for bioinformatics workflows to extract actionable knowledge of transcription regulatory network function.Here, we introduce a five-step computational pipeline, called iModulonMiner, to com
The Enhancer of Zeste 2 (EZH2) protein has been reported to stimulate cell growth in some cancers and is therefore considered to represent an interesting new target for therapeutic intervention.Here, we investigated a possible role of EZH2 for the growth control of colon cancer cells.RNA interference (RNAi)-mediated intracellular EZH2 depletion led